The global pemetrexed market size was valued at USD 2.34 billion in 2024 and is anticipated to reach from USD 2.38 billion in 2025 to USD 2.69 billion by 2033, growing at a CAGR of 1.6% during the forecast period (2025–2033). The growth of the market is attributed to burgeoning consumption of chemotherapy treatments and growing occurrence of non-small lung cancer.

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Market Drivers and Growth Factors

The key driver behind the expansion of the pemetrexed market is the surging consumption of chemotherapy drugs in response to the increasing prevalence of lung cancer and related diseases. Lung cancer remains a leading cause of cancer-related deaths globally, with the World Health Organization reporting approximately 2.5 million new lung cancer cases in 2024 alone. Non-small cell lung cancer accounts for 80% to 85% of all lung cancer diagnoses, with pemetrexed being a recommended treatment for its non-squamous subtype. Malignant pleural mesothelioma, a rare but aggressive cancer linked to asbestos exposure, also contributes to market demand.

Rising environmental pollution, changing lifestyles, and increasing smoking prevalence among younger populations and women have contributed to a growing lung cancer patient pool globally. The availability of generic versions of pemetrexed has expanded patient access, while pharmaceutical players continuously seek to enhance drug efficacy and broaden the approved clinical uses of pemetrexed, further pushing market growth.

Challenges and Market Restraints

Though growth prospects are promising, safety concerns remain a considerable restraint. Pemetrexed treatment can induce adverse side effects such as skin loosening, blistering, lung complications, renal and urinary disorders, hepatobiliary issues, and pneumonitis. These side effects sometimes prompt patients to discontinue treatment, adversely impacting market demand and patient adherence. Furthermore, variations in side effect severity by age and gender also raise safety concerns that may influence the rate of uptake in certain patient demographics.

In regions with limited healthcare infrastructure and lower income levels, such as parts of Latin America, the Middle East, Africa, and some developing countries, restricted government support for cancer treatment hampers market expansion. Lower awareness and diagnostic capabilities in certain populations further challenge market penetration.

Regional Market Insights

North America: Market Leader

North America holds the largest share of the global pemetrexed market. The high prevalence of lung cancer in the U.S. due to factors such as pollution, smoking, and an aging population, combined with widespread healthcare infrastructure, supports sustained demand. The U.S. sees about 3,000 new cases of mesothelioma annually, mostly linked to asbestos exposure. Continuous innovation, including new drug formulations like ready-to-use injections, bolsters growth prospects in this region.

Europe: Mature Market with Strong Presence

Europe captures a significant portion of the market, driven in part by exclusivity patents held by companies like Eli Lilly and Company in key countries including the U.K. Lung cancer remains a leading cause of cancer-related deaths in Europe, accounting for approximately 20% of cancer mortality. Countries like Germany, the U.K., and France contribute notably to regional revenue, supported by advanced healthcare facilities and rising chemotherapy demand.

Asia Pacific: Fastest-Growing Region

Asia Pacific is forecasted to be the fastest-growing market due to growing urbanization, increasing pollution, and expanding healthcare access. China’s large production base and industrial pollution contribute to rising lung cancer cases. India is projected to see a seven-fold increase in lung cancer incidence by 2025 compared to a decade prior, largely due to diagnostic challenges and escalating pollution. Countries like South Korea also report high lung cancer mortality rates despite reductions in smoking. This combination of factors fuels demand for pemetrexed-based therapies in the region.

Latin America, Middle East & Africa (LAMEA): Slower Growth

LAMEA regions have comparatively slower growth rates due to poor healthcare infrastructure and financial constraints. However, progressive improvements in healthcare in countries like Argentina and Brazil offer some market growth opportunities. In the Gulf countries, lung cancer is a major cause of cancer mortality, with a majority of cases diagnosed in advanced stages, underlining the need for improved treatment access and cancer care facilities.

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Market Segmentation

By Application

The market segments based on application include treatment for malignant pleural mesothelioma and non-squamous non-small cell lung cancer. Among these, malignant pleural mesothelioma represents the largest market share due to its strong association with asbestos exposure, a major carcinogen leading to this cancer type. The non-squamous NSCLC segment is anticipated to experience higher growth due to rising smoking rates and increased pollution, particularly affecting younger populations and women.

By End-User

Hospitals and clinics dominate the end-user segment as primary venues for administering chemotherapy drugs including pemetrexed. Growing hospital infrastructure and rising numbers of cancer patients worldwide contribute to this trend. Oncology centers, which provide specialized cancer diagnosis and care, are also witnessing considerable growth due to increasing demand for targeted treatment and advanced therapies. The increased volume of cancer diagnoses intensifies the need for specialized treatment centers.

Recent Innovations and Opportunities

Pharmaceutical companies are actively investing in research and development to improve pemetrexed formulations and expand their indications to maintain competitive advantage. For example, the introduction of ready-to-use injectable forms reduces preparation time and enhances ease of administration for healthcare providers. This innovation streamlines chemotherapy treatment and may improve patient compliance.

Government initiatives supporting cancer research, awareness, and improved healthcare infrastructure worldwide also provide a conducive environment for market growth. These measures aim to increase early diagnosis and access to effective treatments, consequently boosting the demand for drugs like pemetrexed.

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Outlook and Future Prospects

The pemetrexed market is expected to follow a steady growth trajectory over the forecast period, underpinned by rising lung cancer prevalence and continuous pharmaceutical innovation. Despite safety concerns and regional disparities in healthcare access, the overall demand for chemotherapy treatments remains robust.

North America and Europe will continue as mature markets with steady revenue streams, while Asia Pacific will emerge as the most lucrative growth region thanks to rapidly expanding patient populations and healthcare facilities. Developing markets in Latin America and Africa may experience slower but gradual improvements propelled by infrastructure development and increased government support.

The progression toward safer, more convenient pemetrexed formulations, along with expanding indications and enhanced awareness of cancer treatments, positions this market for moderate but sustained growth through 2033.